| 38 | 15:00 Sunday - 25 May | Ipswich Town IPS | - |  West Ham UnitedWHU | Portman Road | Planned |
| 37 | 13:15 Sunday - 18 May | West Ham United WHU | - |  Nottingham ForestNFO | London Stadium | Planned |
| 36 | 14:00 Saturday - 10 May | Manchester United MUN | - | West Ham UnitedWHU | Old Trafford | Planned |
| 35 | 14:00 Saturday - 3 May | West Ham United WHU | - |  Tottenham HotspurTOT | London Stadium | Planned |
| 34 | 14:00 Saturday - 26 April | Brighton & Hove Albion BHA | - | West Ham UnitedWHU | American Express Stadium | Planned |
| 33 | 14:00 Saturday - 19 April | West Ham United WHU | - |  SouthamptonSOU | London Stadium | Planned |
| 32 | 13:00 Sunday - 13 April | Liverpool LIV 6.9 | 2 - 1 | 6.5 West Ham UnitedWHU | Anfield | Fulltime |
| 31 | 14:00 Saturday - 5 April | West Ham United WHU6.6 | 2 - 2 | 6.7 AFC BournemouthBOU | London Stadium | Fulltime |
| 30 | 18:45 Tuesday - 1 April | Wolverhampton Wanderers WOL 7.1 | 1 - 0 | 6.4 West Ham UnitedWHU | Molineux Stadium | Fulltime |
| 29 | 15:00 Saturday - 15 March | Everton EVE 6.7 | 1 - 1 | 6.8 West Ham UnitedWHU | Goodison Park | Fulltime |
| 28 | 20:00 Monday - 10 March | West Ham United WHU6.3 | 0 - 1 | 7.1 Newcastle UnitedNEW | London Stadium | Fulltime |
| 27 | 20:00 Thursday - 27 February | West Ham United WHU7.1 | 2 - 0 | 6.2 Leicester CityLEI | London Stadium | Fulltime |
| 26 | 15:00 Saturday - 22 February | Arsenal ARS 6.4 | 0 - 1 | 7.0 West Ham UnitedWHU | Emirates Stadium | Fulltime |
| 25 | 15:00 Saturday - 15 February | West Ham United WHU6.5 | 0 - 1 | 7.1 BrentfordBRE | London Stadium | Fulltime |
| 24 | 20:00 Monday - 3 February | Chelsea CHE 6.9 | 2 - 1 | 6.3 West Ham UnitedWHU | Stamford Bridge | Fulltime |
| 23 | 16:30 Sunday - 26 January | Aston Villa AVL 6.7 | 1 - 1 | 6.9 West Ham UnitedWHU | Villa Park | Fulltime |
| 22 | 15:00 Saturday - 18 January | West Ham United WHU6.3 | 0 - 2 | 7.2 Crystal PalaceCRY | London Stadium | Fulltime |
| 21 | 19:30 Tuesday - 14 January | West Ham United WHU6.9 | 3 - 2 | 6.3 FulhamFUL | London Stadium | Fulltime |
| 20 | 15:00 Saturday - 4 January | Manchester City MCI 7.1 | 4 - 1 | 6.2 West Ham UnitedWHU | Etihad Stadium | Fulltime |
| 19 | 17:15 Sunday - 29 December | West Ham United WHU6.0 | 0 - 5 | 7.7 LiverpoolLIV | London Stadium | Fulltime |
| 18 | 15:00 Thursday - 26 December | Southampton SOU6.4 | 0 - 1 | 7.0 West Ham UnitedWHU | St. Mary's Stadium | Fulltime |
| 17 | 15:00 Saturday - 21 December | West Ham United WHU6.6 | 1 - 1 | 6.8 Brighton & Hove AlbionBHA | London Stadium | Fulltime |
| 16 | 20:00 Monday - 16 December | AFC Bournemouth BOU6.7 | 1 - 1 | 6.8 West Ham UnitedWHU | Vitality Stadium | Fulltime |
| 15 | 20:00 Monday - 9 December | West Ham United WHU6.9 | 2 - 1 | 6.5 Wolverhampton WanderersWOL | London Stadium | Fulltime |
| 14 | 20:15 Tuesday - 3 December | Leicester City LEI7.3 | 3 - 1 | 6.8 West Ham UnitedWHU | King Power Stadium | Fulltime |
| 13 | 17:30 Saturday - 30 November | West Ham United WHU6.2 | 2 - 5 | 7.3 ArsenalARS | London Stadium | Fulltime |
| 12 | 20:00 Monday - 25 November | Newcastle United NEW6.4 | 0 - 2 | 7.3 West Ham UnitedWHU | St. James' Park | Fulltime |
| 11 | 15:00 Saturday - 9 November | West Ham United WHU6.7 | 0 - 0 | 7.0 EvertonEVE | London Stadium | Fulltime |
| 10 | 15:00 Saturday - 2 November | Nottingham Forest NFO7.3 | 3 - 0 | 6.1 West Ham UnitedWHU | The City Ground | Fulltime |
| 9 | 14:00 Sunday - 27 October | West Ham United WHU7.1 | 2 - 1 | 6.6 Manchester UnitedMUN | London Stadium | Fulltime |
| 8 | 11:30 Saturday - 19 October | Tottenham Hotspur TOT7.3 | 4 - 1 | 6.4 West Ham UnitedWHU | Tottenham Hotspur Stadium | Fulltime |
| 7 | 14:00 Saturday - 5 October | West Ham United WHU7.2 | 4 - 1 | 6.3 Ipswich TownIPS | London Stadium | Fulltime |
| 6 | 14:00 Saturday - 28 September | Brentford BRE6.7 | 1 - 1 | 6.7 West Ham UnitedWHU | Gtech Community Stadium | Fulltime |
| 5 | 11:30 Saturday - 21 September | West Ham United WHU6.3 | 0 - 3 | 7.4 ChelseaCHE | London Stadium | Fulltime |
| 4 | 14:00 Saturday - 14 September | Fulham FUL6.9 | 1 - 1 | 6.5 West Ham UnitedWHU | Craven Cottage | Fulltime |
| 3 | 16:30 Saturday - 31 August | West Ham United WHU6.1 | 1 - 3 | 7.4 Manchester CityMCI | London Stadium | Fulltime |
| 2 | 14:00 Saturday - 24 August | Crystal Palace CRY6.3 | 0 - 2 | 7.2 West Ham UnitedWHU | Selhurst Park | Fulltime |
| 1 | 16:30 Saturday - 17 August | West Ham United WHU6.4 | 1 - 2 | 7.0 Aston VillaAVL | London Stadium | Fulltime |